OS1.6 Characterizing the Over-expression of Yki/YAP/TAZ Transcription Factors in Gliomagenesis and Results of a Phase 0 Clinical Trial for a Proposed Novel Treatment of Glioblastomas

BACKGROUND: Glioblastomas (GBMs) harbor frequent genetic lesions that include amplification, mutation, and/or over expression of receptor tyrosine kinases (RTKs). Using a novel kinome wide RNAi screen we identified the Hippo kinase pathway and it downstream targets, Yki-YAP/TAZ transcription factors...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuro Oncol
Prif Awduron: Vigneswaran, K, Oh, S, Lallani, S, Read, R, Olson, J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2018
Pynciau:
Oral Presentations
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144077/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy139.012
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