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BIOM-60. BIOMARKER EVALUATION FOR IMIPRIDONE ONC206 REVEALS ClpP, ATF4, MYC, EGFR and HIF1 AS KEY PREDICTORS OF ANTI-CANCER EFFICACY

ONC206 is a DRD2 antagonist and ClpP agonist that is a chemical derivative of ONC201, which is in Phase II clinical trials for H3 K27M-mutant glioma. We have previously reported that dopamine receptor expression correlates with ONC201 and ONC206 efficacy. Here, we evaluated additional predictive bio...

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Podrobná bibliografie
Vydáno v:Neuro Oncol
Hlavní autoři: Morrow, Sara, Garnett, Mathew, McDermott, Ultan, Benes, Cyril, Allen, Joshua, Prabhu, Varun
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650352/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.057
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