APOBEC3 enzymes mediate efficacy of cisplatin and are epistatic with base excision repair and mismatch repair in platinum response

Identifying the mechanisms mediating cisplatin response is essential for improving patient response. Previous research has identified base excision repair (BER) and mismatch repair (MMR) activity in sensitizing cells to cisplatin. Cisplatin forms DNA adducts including interstrand cross-links (ICLs)...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:NAR Cancer
Egile Nagusiak: Conner, Kayla L, Shaik, Asra N, Marshall, Katie A, Floyd, Ashley M, Ekinci, Elmira, Lindquist, Jacob, Sawant, Akshada, Lei, Wen, Adolph, Madison B, Chelico, Linda, Siriwardena, Sachini U, Bhagwat, Ashok, Kim, Seongho, Cote, Michele L, Patrick, Steve M
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2020
Gaiak:
DNA Damage Sensing and Repair
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7646253/
https://ncbi.nlm.nih.gov/pubmed/33196045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa033
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