APOBEC3 enzymes mediate efficacy of cisplatin and are epistatic with base excision repair and mismatch repair in platinum response

Identifying the mechanisms mediating cisplatin response is essential for improving patient response. Previous research has identified base excision repair (BER) and mismatch repair (MMR) activity in sensitizing cells to cisplatin. Cisplatin forms DNA adducts including interstrand cross-links (ICLs)...

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Библиографические подробности
Опубликовано в: :NAR Cancer
Главные авторы: Conner, Kayla L, Shaik, Asra N, Marshall, Katie A, Floyd, Ashley M, Ekinci, Elmira, Lindquist, Jacob, Sawant, Akshada, Lei, Wen, Adolph, Madison B, Chelico, Linda, Siriwardena, Sachini U, Bhagwat, Ashok, Kim, Seongho, Cote, Michele L, Patrick, Steve M
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2020
Предметы:
DNA Damage Sensing and Repair
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7646253/
https://ncbi.nlm.nih.gov/pubmed/33196045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa033
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