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Characterization of the Catalytic Domain of Human APOBEC3B and the Critical Structural Role for a Conserved Methionine
Human APOBEC3B deaminates cytosines in DNA and belongs to the AID/APOBEC family of enzymes. These proteins are involved in innate and adaptive immunity, and may cause mutations in a variety of cancers. To characterize its ability to convert cytosines to uracils, we tested several derivatives of APOB...
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| Vydáno v: | J Mol Biol |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4579057/ https://ncbi.nlm.nih.gov/pubmed/26281709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.08.006 |
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