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Characterization of the Catalytic Domain of Human APOBEC3B and the Critical Structural Role for a Conserved Methionine
Human APOBEC3B deaminates cytosines in DNA and belongs to the AID/APOBEC family of enzymes. These proteins are involved in innate and adaptive immunity, and may cause mutations in a variety of cancers. To characterize its ability to convert cytosines to uracils, we tested several derivatives of APOB...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4579057/ https://ncbi.nlm.nih.gov/pubmed/26281709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.08.006 |
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