Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain

Functional and deep sequencing studies have combined to demonstrate the involvement of APOBEC3B in cancer mutagenesis. APOBEC3B is a single-stranded DNA cytosine deaminase that functions normally as a nuclear-localized restriction factor of DNA-based pathogens. However, it is overexpressed in cancer...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Shi, Ke, Carpenter, Michael A., Kurahashi, Kayo, Harris, Reuben S., Aihara, Hideki
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653671/
https://ncbi.nlm.nih.gov/pubmed/26416889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679951
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