Crystal structure of the DNA cytosine deaminase APOBEC3F: the catalytically active and HIV-1 Vif-binding domain

Human APOBEC3F is an anti-retroviral single strand DNA cytosine deaminase, susceptible to degradation by the HIV-1 protein Vif. In this study the crystal structure of the HIV Vif binding, catalytically active, C-terminal domain of APOBEC3F (A3F-CTD) was determined. The A3F-CTD shares structural moti...

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Autori principali: Bohn, Markus-Frederik, Shandilya, Shivender M. D., Albin, John S., Kouno, Takahide, Anderson, Brett D., McDougle, Rebecca M., Carpenter, Michael A., Rathore, Anurag, Evans, Leah, Davis, Ahkillah N., Zhang, Jing Ying, Lu, Yongjian, Somasundaran, Mohan, Matsuo, Hiroshi, Harris, Reuben S., Schiffer, Celia A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805256/
https://ncbi.nlm.nih.gov/pubmed/23685212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.04.010
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