First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G

APOBEC3G is a single-stranded DNA cytosine deaminase that comprises part of the innate immune response to viruses and transposons. Although APOBEC3G is the prototype for understanding the larger mammalian polynucleotide deaminase family, no specific chemical inhibitors exist to modulate its activity...

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Autori principali: Li, Ming, Shandilya, Shivender M.D., Carpenter, Michael A., Rathore, Anurag, Brown, William L., Perkins, Angela L., Harki, Daniel A., Solberg, Jonathan, Hook, Derek J., Pandey, Krishan K., Parniak, Michael A., Johnson, Jeffrey R., Krogan, Nevan J., Somasundaran, Mohan, Ali, Akbar, Schiffer, Celia A., Harris, Reuben S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306499/
https://ncbi.nlm.nih.gov/pubmed/22181350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200440y
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