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Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B
The APOBEC3B (A3B) single-stranded DNA (ssDNA) cytosine deaminase has important roles in innate immunity but is also a major endogenous source of mutations in cancer. Previous structural studies showed that the C-terminal catalytic domain of human A3B has a tightly closed active site, and rearrangem...
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| 發表在: | Sci Rep |
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| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5727031/ https://ncbi.nlm.nih.gov/pubmed/29234087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17694-3 |
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