Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B

The single‐stranded DNA cytosine deaminase APOBEC3B (A3B) functions in innate immunity against viruses, but it is also strongly implicated in eliciting mutations in cancer genomes. Because of the critical role of A3B in promoting virus and tumor evolution, small molecule inhibitors are desirable. Ho...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :FASEB Bioadv
Главные авторы: Shi, Ke, Demir, Özlem, Carpenter, Michael A., Banerjee, Surajit, Harki, Daniel A., Amaro, Rommie E., Harris, Reuben S., Aihara, Hideki
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2019
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996314/
https://ncbi.nlm.nih.gov/pubmed/32123856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fba.2019-00068
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы