Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B

The single‐stranded DNA cytosine deaminase APOBEC3B (A3B) functions in innate immunity against viruses, but it is also strongly implicated in eliciting mutations in cancer genomes. Because of the critical role of A3B in promoting virus and tumor evolution, small molecule inhibitors are desirable. Ho...

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Detalhes bibliográficos
Publicado no:FASEB Bioadv
Main Authors: Shi, Ke, Demir, Özlem, Carpenter, Michael A., Banerjee, Surajit, Harki, Daniel A., Amaro, Rommie E., Harris, Reuben S., Aihara, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996314/
https://ncbi.nlm.nih.gov/pubmed/32123856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fba.2019-00068
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