The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by a RNA-Mediated Dimerization Mechanism

Human APOBEC3H and homologous single-stranded DNA cytosine deaminases are unique to mammals. These DNA editing enzymes function in innate immunity by restricting the replication of viruses and transposons. APOBEC3H also contributes to cancer mutagenesis. Here we address the fundamental nature of RNA...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: Shaban, Nadine M., Shi, Ke, Lauer, Kate V., Carpenter, Michael A., Richards, Christopher M., Salamango, Daniel, Wang, Jiayi, Lopresti, Michael W., Banerjee, Surajit, Levin-Klein, Rena, Brown, William L., Aihara, Hideki, Harris, Reuben S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991973/
https://ncbi.nlm.nih.gov/pubmed/29290613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.12.010
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