The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by a RNA-Mediated Dimerization Mechanism

Human APOBEC3H and homologous single-stranded DNA cytosine deaminases are unique to mammals. These DNA editing enzymes function in innate immunity by restricting the replication of viruses and transposons. APOBEC3H also contributes to cancer mutagenesis. Here we address the fundamental nature of RNA...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell
Prif Awduron: Shaban, Nadine M., Shi, Ke, Lauer, Kate V., Carpenter, Michael A., Richards, Christopher M., Salamango, Daniel, Wang, Jiayi, Lopresti, Michael W., Banerjee, Surajit, Levin-Klein, Rena, Brown, William L., Aihara, Hideki, Harris, Reuben S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991973/
https://ncbi.nlm.nih.gov/pubmed/29290613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.12.010
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