The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by a RNA-Mediated Dimerization Mechanism

Human APOBEC3H and homologous single-stranded DNA cytosine deaminases are unique to mammals. These DNA editing enzymes function in innate immunity by restricting the replication of viruses and transposons. APOBEC3H also contributes to cancer mutagenesis. Here we address the fundamental nature of RNA...

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Udgivet i:Mol Cell
Main Authors: Shaban, Nadine M., Shi, Ke, Lauer, Kate V., Carpenter, Michael A., Richards, Christopher M., Salamango, Daniel, Wang, Jiayi, Lopresti, Michael W., Banerjee, Surajit, Levin-Klein, Rena, Brown, William L., Aihara, Hideki, Harris, Reuben S.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991973/
https://ncbi.nlm.nih.gov/pubmed/29290613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.12.010
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