The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase

Human cells express up to 9 active DNA cytosine deaminases with functions in adaptive and innate immunity. Many cancers manifest an APOBEC mutation signature and APOBEC3B (A3B) is likely the main enzyme responsible. Although significant numbers of APOBEC signature mutations accumulate in tumor genom...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Serebrenik, Artur A., Starrett, Gabriel J., Leenen, Sterre, Jarvis, Matthew C., Shaban, Nadine M., Salamango, Daniel J., Nilsen, Hilde, Brown, William L., Harris, Reuben S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825264/
https://ncbi.nlm.nih.gov/pubmed/31611371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904024116
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