The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase

Human cells express up to 9 active DNA cytosine deaminases with functions in adaptive and innate immunity. Many cancers manifest an APOBEC mutation signature and APOBEC3B (A3B) is likely the main enzyme responsible. Although significant numbers of APOBEC signature mutations accumulate in tumor genom...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Serebrenik, Artur A., Starrett, Gabriel J., Leenen, Sterre, Jarvis, Matthew C., Shaban, Nadine M., Salamango, Daniel J., Nilsen, Hilde, Brown, William L., Harris, Reuben S.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825264/
https://ncbi.nlm.nih.gov/pubmed/31611371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904024116
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