Endogenous APOBEC3A DNA Cytosine Deaminase Is Cytoplasmic and Nongenotoxic

APOBEC3A (A3A) is a myeloid lineage-specific DNA cytosine deaminase with a role in innate immunity to foreign DNA. Previous studies have shown that heterologously expressed A3A is genotoxic, suggesting that monocytes may have a mechanism to regulate this enzyme. Indeed, we observed no significant cy...

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Bibliographic Details
Main Authors: Land, Allison M., Law, Emily K., Carpenter, Michael A., Lackey, Lela, Brown, William L., Harris, Reuben S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682529/
https://ncbi.nlm.nih.gov/pubmed/23640892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.458661
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