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Endogenous APOBEC3A DNA Cytosine Deaminase Is Cytoplasmic and Nongenotoxic
APOBEC3A (A3A) is a myeloid lineage-specific DNA cytosine deaminase with a role in innate immunity to foreign DNA. Previous studies have shown that heterologously expressed A3A is genotoxic, suggesting that monocytes may have a mechanism to regulate this enzyme. Indeed, we observed no significant cy...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3682529/ https://ncbi.nlm.nih.gov/pubmed/23640892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.458661 |
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