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A computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif

APOBEC3s (A3) are Zn(2+) dependent cytidine deaminases with diverse biological functions and implications for cancer and immunity. Four of the seven human A3s restrict HIV by 'hypermutating' the reverse-transcribed viral genomic DNA. HIV Virion Infectivity Factor (Vif) counters this restri...

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Bibliografische gegevens
Gepubliceerd in:Virology
Hoofdauteurs: Shandilya, M.D. Shivender, Bohn, Markus-Frederik, Schiffer, Celia A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857191/
https://ncbi.nlm.nih.gov/pubmed/25461536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.09.023
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