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A computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif
APOBEC3s (A3) are Zn(2+) dependent cytidine deaminases with diverse biological functions and implications for cancer and immunity. Four of the seven human A3s restrict HIV by 'hypermutating' the reverse-transcribed viral genomic DNA. HIV Virion Infectivity Factor (Vif) counters this restri...
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| Publicado en: | Virology |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4857191/ https://ncbi.nlm.nih.gov/pubmed/25461536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.09.023 |
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