Crystal Structure of DNA Cytidine Deaminase ABOBEC3G Catalytic Deamination Domain Suggests a Binding Mode of Full-length Enzyme to Single-stranded DNA

APOBEC3G (A3G) is a DNA cytidine deaminase (CD) that demonstrates antiviral activity against human immunodeficiency virus 1 (HIV-1) and other pathogenic virus. It has an inactive N-terminal CD1 virus infectivity factor (Vif) protein binding domain (A3G-CD1) and an actively catalytic C-terminal CD2 d...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Principais autores: Lu, Xiuxiu, Zhang, Tianlong, Xu, Zeng, Liu, Shanshan, Zhao, Bin, Lan, Wenxian, Wang, Chunxi, Ding, Jianping, Cao, Chunyang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326812/
https://ncbi.nlm.nih.gov/pubmed/25542899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.624262
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