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Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

Activation-induced cytidine deaminase (AID) is required for the maturation of antibodies in higher vertebrates, where it promotes somatic hypermutation (SHM), class switch recombination and gene conversion. While it is known that SHM requires high levels of transcription of the target genes, it is u...

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Main Authors: Sohail, Anjum, Klapacz, Joanna, Samaranayake, Mala, Ullah, Asad, Bhagwat, Ashok S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2003
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC162340/
https://ncbi.nlm.nih.gov/pubmed/12799424
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