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Transcriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase

Transcription of the rearranged immunoglobulin gene and expression of the enzyme activation-induced deaminase (AID) are essential for somatic hypermutations of this gene during antibody maturation. While AID acts as a single-strand DNA-cytosine deaminase creating U · G mispairs that lead to mutation...

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Bibliografiske detaljer
Main Authors: Canugovi, Chandrika, Samaranayake, Mala, Bhagwat, Ashok S.
Format: Artigo
Sprog:Inglês
Udgivet: The Federation of American Societies for Experimental Biology 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626617/
https://ncbi.nlm.nih.gov/pubmed/18772346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-115352
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