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Transcriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase
Transcription of the rearranged immunoglobulin gene and expression of the enzyme activation-induced deaminase (AID) are essential for somatic hypermutations of this gene during antibody maturation. While AID acts as a single-strand DNA-cytosine deaminase creating U · G mispairs that lead to mutation...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Federation of American Societies for Experimental Biology
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2626617/ https://ncbi.nlm.nih.gov/pubmed/18772346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-115352 |
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