A Tumor-Promoting Phorbol Ester Causes a Large Increase in APOBEC3A Expression and a Moderate Increase in APOBEC3B Expression in a Normal Human Keratinocyte Cell Line without Increasing Genomic Uracils

Phorbol 12-myristate 13-acetate (PMA) promotes skin cancer in rodents. The mutations found in murine tumors are similar to those found in human skin cancers, and PMA promotes proliferation of human skin cells. PMA treatment of human keratinocytes increases the synthesis of APOBEC3A, an enzyme that c...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Siriwardena, Sachini U., Perera, Madusha L. W., Senevirathne, Vimukthi, Stewart, Jessica, Bhagwat, Ashok S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290372/
https://ncbi.nlm.nih.gov/pubmed/30348839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00238-18
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