APOBEC3 enzymes mediate efficacy of cisplatin and are epistatic with base excision repair and mismatch repair in platinum response

Identifying the mechanisms mediating cisplatin response is essential for improving patient response. Previous research has identified base excision repair (BER) and mismatch repair (MMR) activity in sensitizing cells to cisplatin. Cisplatin forms DNA adducts including interstrand cross-links (ICLs)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:NAR Cancer
Prif Awduron: Conner, Kayla L, Shaik, Asra N, Marshall, Katie A, Floyd, Ashley M, Ekinci, Elmira, Lindquist, Jacob, Sawant, Akshada, Lei, Wen, Adolph, Madison B, Chelico, Linda, Siriwardena, Sachini U, Bhagwat, Ashok, Kim, Seongho, Cote, Michele L, Patrick, Steve M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2020
Pynciau:
DNA Damage Sensing and Repair
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7646253/
https://ncbi.nlm.nih.gov/pubmed/33196045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa033
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg