Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle()

Loss of long-term hematopoietic stem cell (LT-HSC) function ex vivo hampers the success of clinical protocols that rely on culture. However, the kinetics and mechanisms through which this occurs remain incompletely characterized. In this study, through time-resolved single-cell RNA sequencing, match...

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Publicado en:Blood
Autores principales: Johnson, Carys S., Williams, Matthew, Sham, Kendig, Belluschi, Serena, Ma, Wenjuan, Wang, Xiaonan, Lau, Winnie W. Y., Kaufmann, Kerstin B., Krivdova, Gabriela, Calderbank, Emily F., Mende, Nicole, McLeod, Jessica, Mantica, Giovanna, Li, Juan, Grey-Wilson, Charlotte, Drakopoulos, Michael, Basheer, Shaaezmeen, Sinha, Shubhankar, Diamanti, Evangelia, Basford, Christina, Wilson, Nicola K., Howe, Steven J., Dick, John E., Göttgens, Berthold, Green, Anthony R., Francis, Natalie, Laurenti, Elisa
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society of Hematology 2024
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616366/
https://ncbi.nlm.nih.gov/pubmed/38805639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2023021426
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