Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle()

Loss of long-term hematopoietic stem cell (LT-HSC) function ex vivo hampers the success of clinical protocols that rely on culture. However, the kinetics and mechanisms through which this occurs remain incompletely characterized. In this study, through time-resolved single-cell RNA sequencing, match...

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Udgivet i:Blood
Main Authors: Johnson, Carys S., Williams, Matthew, Sham, Kendig, Belluschi, Serena, Ma, Wenjuan, Wang, Xiaonan, Lau, Winnie W. Y., Kaufmann, Kerstin B., Krivdova, Gabriela, Calderbank, Emily F., Mende, Nicole, McLeod, Jessica, Mantica, Giovanna, Li, Juan, Grey-Wilson, Charlotte, Drakopoulos, Michael, Basheer, Shaaezmeen, Sinha, Shubhankar, Diamanti, Evangelia, Basford, Christina, Wilson, Nicola K., Howe, Steven J., Dick, John E., Göttgens, Berthold, Green, Anthony R., Francis, Natalie, Laurenti, Elisa
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Hematology 2024
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616366/
https://ncbi.nlm.nih.gov/pubmed/38805639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2023021426
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