Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors

Capturing where and how multipotency is lost is crucial to understand how blood formation is controlled. Blood lineage specification is currently thought to occur downstream of multipotent haematopoietic stem cells (HSC). Here we show that, in human, the first lineage restriction events occur within...

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Udgivet i:Nat Commun
Main Authors: Belluschi, Serena, Calderbank, Emily F., Ciaurro, Valerio, Pijuan-Sala, Blanca, Santoro, Antonella, Mende, Nicole, Diamanti, Evangelia, Sham, Kendig Yen Chi, Wang, Xiaonan, Lau, Winnie W. Y., Jawaid, Wajid, Göttgens, Berthold, Laurenti, Elisa
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173731/
https://ncbi.nlm.nih.gov/pubmed/30291229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06442-4
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