Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors

Capturing where and how multipotency is lost is crucial to understand how blood formation is controlled. Blood lineage specification is currently thought to occur downstream of multipotent haematopoietic stem cells (HSC). Here we show that, in human, the first lineage restriction events occur within...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Belluschi, Serena, Calderbank, Emily F., Ciaurro, Valerio, Pijuan-Sala, Blanca, Santoro, Antonella, Mende, Nicole, Diamanti, Evangelia, Sham, Kendig Yen Chi, Wang, Xiaonan, Lau, Winnie W. Y., Jawaid, Wajid, Göttgens, Berthold, Laurenti, Elisa
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173731/
https://ncbi.nlm.nih.gov/pubmed/30291229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06442-4
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