STAT1 is essential for HSC function and maintains MHCII(hi) stem cells that resist myeloablation and neoplastic expansion

Adult hematopoietic stem cells (HSCs) are predominantly quiescent and can be activated in response to acute stress such as infection or cytotoxic insults. STAT1 is a pivotal downstream mediator of interferon (IFN) signaling and is required for IFN-induced HSC proliferation, but little is known about...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Li, Juan, Williams, Matthew J., Park, Hyun Jung, Bastos, Hugo P., Wang, Xiaonan, Prins, Daniel, Wilson, Nicola K., Johnson, Carys, Sham, Kendig, Wantoch, Michelle, Watcham, Sam, Kinston, Sarah J., Pask, Dean C., Hamilton, Tina L., Sneade, Rachel, Waller, Amie K., Ghevaert, Cedric, Vassiliou, George S., Laurenti, Elisa, Kent, David G., Göttgens, Berthold, Green, Anthony R.
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Hematology 2022
Matèries:
Hematopoiesis and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614316/
https://ncbi.nlm.nih.gov/pubmed/35767701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2021014009
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