HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus

BACKGROUND: The P140 phosphopeptide issued from the spliceosomal U1-70K small nuclear ribonucleoprotein protein displays protective properties in MRL/lpr lupus-prone mice. It binds both major histocompatibility class II (MHCII) and HSC70/Hsp73 molecules. P140 peptide increases MRL/lpr peripheral blo...

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Detalhes bibliográficos
Main Authors: Page, Nicolas, Gros, Frédéric, Schall, Nicolas, Décossas, Marion, Bagnard, Dominique, Briand, Jean-Paul, Muller, Sylviane
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2010
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070272/
https://ncbi.nlm.nih.gov/pubmed/21173017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2010.139832
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