Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model

Por Alzubi, Jamal, Pallant, Celeste, Mussolino, Claudio, Howe, Steven J., Thrasher, Adrian J., Cathomen, Toni
Publicado no Sci Rep (2017)

Tolerance Induction Using Lentiviral Gene Delivery Delays Onset and Severity of Collagen II Arthritis

Por Gjertsson, Inger, Laurie, Karen L, Devitt, James, Howe, Steven J, Thrasher, Adrian J, Holmdahl, Rikard, Gustafsson, Kenth
Publicado em 2009

Inhibition of Mitochondrial Complex I Impairs Release of α-Galactosidase by Jurkat Cells

Por Lambert, Jonathan R. A., Howe, Steven J., Rahim, Ahad A., Burke, Derek G., Heales, Simon J. R.
Publicado no Int J Mol Sci (2019)

Minicircle DNA Provides Enhanced and Prolonged Transgene Expression Following Airway Gene Transfer

Por Munye, Mustafa M., Tagalakis, Aristides D., Barnes, Josephine L., Brown, Rachel E., McAnulty, Robin J., Howe, Steven J., Hart, Stephen L.
Publicado no Sci Rep (2016)

Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cel...

Por Zhang, Fang, Thornhill, Susannah I., Howe, Steven J., Ulaganathan, Meera, Schambach, Axel, Sinclair, Joanna, Kinnon, Christine, Gaspar, H. Bobby, Antoniou, Michael, Thrasher, Adrian J.
Publicado em 2007

Perinatal Gene Transfer to the Liver

Por McKay, Tristan R, Rahim, Ahad A, Buckley, Suzanne M.K, Ward, Natalie J, Chan, Jerry K.Y, Howe, Steven J, Waddington, Simon N
Publicado em 2011

Evidence for Contribution of CD4+CD25+ Regulatory T Cells in Maintaining Immune Tolerance to Human Factor IX following Perinatal Adenovirus Vector Delivery

Por Nivsarkar, Megha S., Buckley, Suzanne M. K., Parker, Alan L., Perocheau, Dany, McKay, Tristan R., Rahim, Ahad A., Howe, Steven J., Waddington, Simon N.
Publicado no J Immunol Res (2015)

Gene Delivery of a Mutant TGFβ3 Reduces Markers of Scar Tissue Formation After Cutaneous Wounding

Por Waddington, Simon N, Crossley, Rachel, Sheard, Vicky, Howe, Steven J, Buckley, Suzanne MK, Coughlan, Lynda, Gilham, David E, Hawkins, Robert E, McKay, Tristan R
Publicado em 2010

The Landscape of Early Clinical Gene Therapies outside of Oncology

Por Rittié, Laure, Athanasopoulos, Takis, Calero-Garcia, Miguel, Davies, Marie L., Dow, David J., Howe, Steven J., Morrison, Alastair, Ricciardelli, Ida, Saudemont, Aurore, Jespers, Laurent, Clay, Timothy M.
Publicado no Mol Ther (2019)

Lentiviral vectors can be used for full-length dystrophin gene therapy

Por Counsell, John R., Asgarian, Zeinab, Meng, Jinhong, Ferrer, Veronica, Vink, Conrad A., Howe, Steven J., Waddington, Simon N., Thrasher, Adrian J., Muntoni, Francesco, Morgan, Jennifer E., Danos, Olivier
Publicado no Sci Rep (2017)

Lentiviral vectors can be used for full-length dystrophin gene therapy

Por Counsell, John R., Asgarian, Zeinab, Meng, Jinhong, Ferrer, Veronica, Vink, Conrad A., Howe, Steven J., Waddington, Simon N., Thrasher, Adrian J., Muntoni, Francesco, Morgan, Jennifer E., Danos, Olivier
Publicado no Sci Rep (2017)

Erratum: Lentiviral vectors can be used for full-length dystrophin gene therapy

Por Counsell, John R., Asgarian, Zeinab, Meng, Jinhong, Ferrer, Veronica, Vink, Conrad A., Howe, Steven J., Waddington, Simon N., Thrasher, Adrian J., Muntoni, Francesco, Morgan, Jennifer E., Danos, Olivier
Publicado no Sci Rep (2017)

Self-inactivating Gammaretroviral Vectors for Gene Therapy of X-linked Severe Combined Immunodeficiency

Por Thornhill, Susannah I, Schambach, Axel, Howe, Steven J, Ulaganathan, Meera, Grassman, Elke, Williams, David, Schiedlmeier, Bernhard, Sebire, Neil J, Gaspar, H Bobby, Kinnon, Christine, Baum, Christopher, Thrasher, Adrian J
Publicado no Mol Ther (2008)

BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity

Por Munye, Mustafa M., Shoemark, Amelia, Hirst, Robert A., Delhove, Juliette M., Sharp, Tyson V., McKay, Tristan R., O’Callaghan, Christopher, Baines, Deborah L., Howe, Steven J., Hart, Stephen L.
Publicado no Am J Physiol Lung Cell Mol Physiol (2017)

Enhancement of mouse hematopoietic stem/progenitor cell function via transient gene delivery using integration-deficient lentiviral vectors

Por Alonso-Ferrero, Maria E., van Til, Niek P., Bartolovic, Kerol, Mata, Márcia F., Wagemaker, Gerard, Moulding, Dale, Williams, David A., Kinnon, Christine, Waddington, Simon N., Milsom, Michael D., Howe, Steven J.
Publicado no Exp Hematol (2018)

Systemic gene delivery following intravenous administration of AAV9 to fetal and neonatal mice and late-gestation nonhuman primates

Por Mattar, Citra N., Wong, Andrew M. S., Hoefer, Klemens, Alonso-Ferrero, Maria E., Buckley, Suzanne M. K., Howe, Steven J., Cooper, Jonathan D., Waddington, Simon N., Chan, Jerry K. Y., Rahim, Ahad A.
Publicado no FASEB J (2015)

Eliminating HIV-1 Packaging Sequences from Lentiviral Vector Proviruses Enhances Safety and Expedites Gene Transfer for Gene Therapy

Por Vink, Conrad A., Counsell, John R., Perocheau, Dany P., Karda, Rajvinder, Buckley, Suzanne M.K., Brugman, Martijn H., Galla, Melanie, Schambach, Axel, McKay, Tristan R., Waddington, Simon N., Howe, Steven J.
Publicado no Mol Ther (2017)

Hematopoietic Stem Cell and Gene Therapy Corrects Primary Neuropathology and Behavior in Mucopolysaccharidosis IIIA Mice

Por Langford-Smith, Alexander, Wilkinson, Fiona L, Langford-Smith, Kia J, Holley, Rebecca J, Sergijenko, Ana, Howe, Steven J, Bennett, William R, Jones, Simon A, Wraith, JE, Merry, Catherine LR, Wynn, Robert F, Bigger, Brian W
Publicado em 2012

In vivo bioimaging with tissue-specific transcription factor activated luciferase reporters

Por Buckley, Suzanne M. K., Delhove, Juliette M. K. M., Perocheau, Dany P., Karda, Rajvinder, Rahim, Ahad A., Howe, Steven J., Ward, Natalie J., Birrell, Mark A., Belvisi, Maria G., Arbuthnot, Patrick, Johnson, Mark R., Waddington, Simon N., McKay, Tristan R.
Publicado no Sci Rep (2015)

Lentiviral Vector Integration Profiles Differ in Rodent Postmitotic Tissues

Por Bartholomae, Cynthia C, Arens, Anne, Balaggan, Kamaljit S, Yáñez-Muñoz, Rafael J, Montini, Eugenio, Howe, Steven J, Paruzynski, Anna, Korn, Bernhard, Appelt, Jens Uwe, MacNeil, Angus, Cesana, Daniela, Abel, Ulrich, Glimm, Hanno, Naldini, Luigi, Ali, Robin R, Thrasher, Adrian J, von Kalle, Christof, Schmidt, Manfred
Publicado em 2011