Tolerance Induction Using Lentiviral Gene Delivery Delays Onset and Severity of Collagen II Arthritis

The treatment of rheumatoid arthritis remains suboptimal; thus there is considerable interest in the development of strategies that mediate tolerance to autoantigens. Using lentiviral gene transfer in vivo, we expressed the immunodominant epitope of collagen type II (CII) on major histocompatibility...

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Autors principals: Gjertsson, Inger, Laurie, Karen L, Devitt, James, Howe, Steven J, Thrasher, Adrian J, Holmdahl, Rikard, Gustafsson, Kenth
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2009
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835107/
https://ncbi.nlm.nih.gov/pubmed/19174762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.299
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