Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis

Here, we investigate induction of immunological tolerance by lentiviral based gene therapy in a mouse model of rheumatoid arthritis, collagen II-induced arthritis (CIA). Targeting the expression of the collagen type II (CII) to antigen presenting cells (APCs) induced antigen-specific tolerance, wher...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Tengvall, Sara, Eneljung, Tove, Jirholt, Pernilla, Turesson, Olof, Wing, Kajsa, Holmdahl, Rikard, Kihlberg, Jan, Stern, Anna, Mårtensson, Inga-Lill, Henningsson, Louise, Gustafsson, Kenth, Gjertsson, Inger
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861286/
https://ncbi.nlm.nih.gov/pubmed/27159398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154630
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