Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle()

Loss of long-term hematopoietic stem cell (LT-HSC) function ex vivo hampers the success of clinical protocols that rely on culture. However, the kinetics and mechanisms through which this occurs remain incompletely characterized. In this study, through time-resolved single-cell RNA sequencing, match...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Johnson, Carys S., Williams, Matthew, Sham, Kendig, Belluschi, Serena, Ma, Wenjuan, Wang, Xiaonan, Lau, Winnie W. Y., Kaufmann, Kerstin B., Krivdova, Gabriela, Calderbank, Emily F., Mende, Nicole, McLeod, Jessica, Mantica, Giovanna, Li, Juan, Grey-Wilson, Charlotte, Drakopoulos, Michael, Basheer, Shaaezmeen, Sinha, Shubhankar, Diamanti, Evangelia, Basford, Christina, Wilson, Nicola K., Howe, Steven J., Dick, John E., Göttgens, Berthold, Green, Anthony R., Francis, Natalie, Laurenti, Elisa
Format: Artigo
Langue:Inglês
Publié: The American Society of Hematology 2024
Sujets:
Hematopoiesis and Stem Cells
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616366/
https://ncbi.nlm.nih.gov/pubmed/38805639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2023021426
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires