A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice

Hematopoietic stem and progenitor cells (HSPCs) maintain the adult blood system, and their dysregulation causes a multitude of diseases. However, the differentiation journeys toward specific hematopoietic lineages remain ill defined, and system-wide disease interpretation remains challenging. Here,...

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Bibliographic Details
Published in:Blood
Main Authors: Dahlin, Joakim S., Hamey, Fiona K., Pijuan-Sala, Blanca, Shepherd, Mairi, Lau, Winnie W. Y., Nestorowa, Sonia, Weinreb, Caleb, Wolock, Samuel, Hannah, Rebecca, Diamanti, Evangelia, Kent, David G., Göttgens, Berthold, Wilson, Nicola K.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2018
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969381/
https://ncbi.nlm.nih.gov/pubmed/29588278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-12-821413
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