Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting

The nascent polypeptide-associated complex (NAC) interacts with newly synthesized proteins at the ribosomal tunnel exit. NAC competes with the signal recognition particle (SRP) to prevent mistargeting of cytosolic and mitochondrial polypeptides to the endoplasmic reticulum (ER). How NAC antagonizes...

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Bibliographic Details
Published in:Science
Main Authors: Jomaa, Ahmad, Gamerdinger, Martin, Hsieh, Hao-Hsuan, Wallisch, Annalena, Chandrasekaran, Viswanathan, Ulusoy, Zeynel, Scaiola, Alain, Hegde, Ramanujan S., Shan, Shu-ou, Ban, Nenad, Deuerling, Elke
Format: Artigo
Language:Inglês
Published: 2022
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612438/
https://ncbi.nlm.nih.gov/pubmed/35201867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abl6459
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