Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting

The nascent polypeptide-associated complex (NAC) interacts with newly synthesized proteins at the ribosomal tunnel exit. NAC competes with the signal recognition particle (SRP) to prevent mistargeting of cytosolic and mitochondrial polypeptides to the endoplasmic reticulum (ER). How NAC antagonizes...

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發表在:Science
Main Authors: Jomaa, Ahmad, Gamerdinger, Martin, Hsieh, Hao-Hsuan, Wallisch, Annalena, Chandrasekaran, Viswanathan, Ulusoy, Zeynel, Scaiola, Alain, Hegde, Ramanujan S., Shan, Shu-ou, Ban, Nenad, Deuerling, Elke
格式: Artigo
語言:Inglês
出版: 2022
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612438/
https://ncbi.nlm.nih.gov/pubmed/35201867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abl6459
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