Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting

The nascent polypeptide-associated complex (NAC) interacts with newly synthesized proteins at the ribosomal tunnel exit. NAC competes with the signal recognition particle (SRP) to prevent mistargeting of cytosolic and mitochondrial polypeptides to the endoplasmic reticulum (ER). How NAC antagonizes...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Jomaa, Ahmad, Gamerdinger, Martin, Hsieh, Hao-Hsuan, Wallisch, Annalena, Chandrasekaran, Viswanathan, Ulusoy, Zeynel, Scaiola, Alain, Hegde, Ramanujan S., Shan, Shu-ou, Ban, Nenad, Deuerling, Elke
Formato: Artigo
Idioma:Inglês
Publicado em: 2022
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612438/
https://ncbi.nlm.nih.gov/pubmed/35201867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abl6459
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