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Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER

The conserved signal recognition particle (SRP) cotranslationally delivers ~30% of the proteome to the eukaryotic endoplasmic reticulum (ER). The molecular mechanism by which eukaryotic SRP transitions from cargo recognition in the cytosol to protein translocation at the ER is not understood. Here,...

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Bibliografiska uppgifter
I publikationen:Sci Adv
Huvudupphovsmän: Lee, Jae Ho, Jomaa, Ahmad, Chung, SangYoon, Hwang Fu, Yu-Hsien, Qian, Ruilin, Sun, Xuemeng, Hsieh, Hao-Hsuan, Chandrasekar, Sowmya, Bi, Xiaotian, Mattei, Simone, Boehringer, Daniel, Weiss, Shimon, Ban, Nenad, Shan, Shu-ou
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Association for the Advancement of Science 2021
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139590/
https://ncbi.nlm.nih.gov/pubmed/34020957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg0942
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