Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER

The conserved signal recognition particle (SRP) cotranslationally delivers ~30% of the proteome to the eukaryotic endoplasmic reticulum (ER). The molecular mechanism by which eukaryotic SRP transitions from cargo recognition in the cytosol to protein translocation at the ER is not understood. Here,...

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Dades bibliogràfiques
Publicat a:Sci Adv
Autors principals: Lee, Jae Ho, Jomaa, Ahmad, Chung, SangYoon, Hwang Fu, Yu-Hsien, Qian, Ruilin, Sun, Xuemeng, Hsieh, Hao-Hsuan, Chandrasekar, Sowmya, Bi, Xiaotian, Mattei, Simone, Boehringer, Daniel, Weiss, Shimon, Ban, Nenad, Shan, Shu-ou
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139590/
https://ncbi.nlm.nih.gov/pubmed/34020957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg0942
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