Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER

The conserved signal recognition particle (SRP) cotranslationally delivers ~30% of the proteome to the eukaryotic endoplasmic reticulum (ER). The molecular mechanism by which eukaryotic SRP transitions from cargo recognition in the cytosol to protein translocation at the ER is not understood. Here,...

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Publicado en:Sci Adv
Autores principales: Lee, Jae Ho, Jomaa, Ahmad, Chung, SangYoon, Hwang Fu, Yu-Hsien, Qian, Ruilin, Sun, Xuemeng, Hsieh, Hao-Hsuan, Chandrasekar, Sowmya, Bi, Xiaotian, Mattei, Simone, Boehringer, Daniel, Weiss, Shimon, Ban, Nenad, Shan, Shu-ou
Formato: Artigo
Lenguaje:Inglês
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139590/
https://ncbi.nlm.nih.gov/pubmed/34020957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg0942
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