Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER

The conserved signal recognition particle (SRP) cotranslationally delivers ~30% of the proteome to the eukaryotic endoplasmic reticulum (ER). The molecular mechanism by which eukaryotic SRP transitions from cargo recognition in the cytosol to protein translocation at the ER is not understood. Here,...

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Библиографические подробности
Опубликовано в: :Sci Adv
Главные авторы: Lee, Jae Ho, Jomaa, Ahmad, Chung, SangYoon, Hwang Fu, Yu-Hsien, Qian, Ruilin, Sun, Xuemeng, Hsieh, Hao-Hsuan, Chandrasekar, Sowmya, Bi, Xiaotian, Mattei, Simone, Boehringer, Daniel, Weiss, Shimon, Ban, Nenad, Shan, Shu-ou
Формат: Artigo
Язык:Inglês
Опубликовано: American Association for the Advancement of Science 2021
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139590/
https://ncbi.nlm.nih.gov/pubmed/34020957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg0942
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