Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters

The MYC oncoprotein globally affects the function of RNA Polymerase II (RNAPII). The ability of MYC to promote transcription elongation depends on its ubiquitylation. Here we show that MYC and PAF1c (Polymerase II associated factor 1 complex) interact directly and mutually enhance each other´s assoc...

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Publicado en:Mol Cell
Main Authors: Endres, Theresa, Solvie, Daniel, Heidelberger, Jan B., Andrioletti, Valentina, Baluapuri, Apoorva, Ade, Carsten P., Muhar, Matthias, Eilers, Ursula, Vos, Seychelle M., Cramer, Patrick, Zuber, Johannes, Beli, Petra, Popov, Nikita, Wolf, Elmar, Gallant, Peter, Eilers, Martin
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611325/
https://ncbi.nlm.nih.gov/pubmed/33453168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.12.035
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