MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma

Deregulated expression of the MYC oncoprotein enables tumor cells to evade immune surveillance, but the mechanisms underlying this surveillance are poorly understood. We show here that endogenous MYC protects pancreatic ductal adenocarcinoma driven by KRAS(G12D) and TP53(R172H) from eradication by t...

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Krenz, Bastian, Gebhardt-Wolf, Anneli, Ade, Carsten P., Gaballa, Abdallah, Roehrig, Florian, Vendelova, Emilia, Baluapuri, Apoorva, Eilers, Ursula, Gallant, Peter, D’Artista, Luana, Wiegering, Armin, Gasteiger, Georg, Rosenfeldt, Mathias T., Bauer, Stefan, Zender, Lars, Wolf, Elmar, Eilers, Martin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611539/
https://ncbi.nlm.nih.gov/pubmed/34145038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-21-1677
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