MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma

Deregulated expression of the MYC oncoprotein enables tumor cells to evade immune surveillance, but the mechanisms underlying this surveillance are poorly understood. We show here that endogenous MYC protects pancreatic ductal adenocarcinoma driven by KRAS(G12D) and TP53(R172H) from eradication by t...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Krenz, Bastian, Gebhardt-Wolf, Anneli, Ade, Carsten P., Gaballa, Abdallah, Roehrig, Florian, Vendelova, Emilia, Baluapuri, Apoorva, Eilers, Ursula, Gallant, Peter, D’Artista, Luana, Wiegering, Armin, Gasteiger, Georg, Rosenfeldt, Mathias T., Bauer, Stefan, Zender, Lars, Wolf, Elmar, Eilers, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611539/
https://ncbi.nlm.nih.gov/pubmed/34145038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-21-1677
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