MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma

Deregulated expression of the MYC oncoprotein enables tumor cells to evade immune surveillance, but the mechanisms underlying this surveillance are poorly understood. We show here that endogenous MYC protects pancreatic ductal adenocarcinoma driven by KRAS(G12D) and TP53(R172H) from eradication by t...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Res
Auteurs principaux: Krenz, Bastian, Gebhardt-Wolf, Anneli, Ade, Carsten P., Gaballa, Abdallah, Roehrig, Florian, Vendelova, Emilia, Baluapuri, Apoorva, Eilers, Ursula, Gallant, Peter, D’Artista, Luana, Wiegering, Armin, Gasteiger, Georg, Rosenfeldt, Mathias T., Bauer, Stefan, Zender, Lars, Wolf, Elmar, Eilers, Martin
Format: Artigo
Langue:Inglês
Publié: 2021
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611539/
https://ncbi.nlm.nih.gov/pubmed/34145038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-21-1677
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires