Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters

The MYC oncoprotein globally affects the function of RNA Polymerase II (RNAPII). The ability of MYC to promote transcription elongation depends on its ubiquitylation. Here we show that MYC and PAF1c (Polymerase II associated factor 1 complex) interact directly and mutually enhance each other´s assoc...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cell
Egile Nagusiak: Endres, Theresa, Solvie, Daniel, Heidelberger, Jan B., Andrioletti, Valentina, Baluapuri, Apoorva, Ade, Carsten P., Muhar, Matthias, Eilers, Ursula, Vos, Seychelle M., Cramer, Patrick, Zuber, Johannes, Beli, Petra, Popov, Nikita, Wolf, Elmar, Gallant, Peter, Eilers, Martin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611325/
https://ncbi.nlm.nih.gov/pubmed/33453168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.12.035
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