Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters

The MYC oncoprotein globally affects the function of RNA Polymerase II (RNAPII). The ability of MYC to promote transcription elongation depends on its ubiquitylation. Here we show that MYC and PAF1c (Polymerase II associated factor 1 complex) interact directly and mutually enhance each other´s assoc...

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Pubblicato in:Mol Cell
Autori principali: Endres, Theresa, Solvie, Daniel, Heidelberger, Jan B., Andrioletti, Valentina, Baluapuri, Apoorva, Ade, Carsten P., Muhar, Matthias, Eilers, Ursula, Vos, Seychelle M., Cramer, Patrick, Zuber, Johannes, Beli, Petra, Popov, Nikita, Wolf, Elmar, Gallant, Peter, Eilers, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611325/
https://ncbi.nlm.nih.gov/pubmed/33453168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.12.035
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