MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation

The MYC oncoprotein binds to promoter-proximal regions of virtually all transcribed genes and enhances RNA polymerase II (Pol II) function, but its precise mode of action is poorly understood. Using mass spectrometry of both MYC and Pol II complexes, we show here that MYC controls the assembly of Po...

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Publicado en:Mol Cell
Main Authors: Baluapuri, Apoorva, Hofstetter, Julia, Dudvarski Stankovic, Nevenka, Endres, Theresa, Bhandare, Pranjali, Vos, Seychelle Monique, Adhikari, Bikash, Schwarz, Jessica Denise, Narain, Ashwin, Vogt, Markus, Wang, Shuang-Yan, Düster, Robert, Jung, Lisa Anna, Vanselow, Jens Thorsten, Wiegering, Armin, Geyer, Matthias, Maric, Hans Michael, Gallant, Peter, Walz, Susanne, Schlosser, Andreas, Cramer, Patrick, Eilers, Martin, Wolf, Elmar
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527870/
https://ncbi.nlm.nih.gov/pubmed/30928206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.02.031
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