MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation

The MYC oncoprotein binds to promoter-proximal regions of virtually all transcribed genes and enhances RNA polymerase II (Pol II) function, but its precise mode of action is poorly understood. Using mass spectrometry of both MYC and Pol II complexes, we show here that MYC controls the assembly of Po...

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發表在:Mol Cell
Main Authors: Baluapuri, Apoorva, Hofstetter, Julia, Dudvarski Stankovic, Nevenka, Endres, Theresa, Bhandare, Pranjali, Vos, Seychelle Monique, Adhikari, Bikash, Schwarz, Jessica Denise, Narain, Ashwin, Vogt, Markus, Wang, Shuang-Yan, Düster, Robert, Jung, Lisa Anna, Vanselow, Jens Thorsten, Wiegering, Armin, Geyer, Matthias, Maric, Hans Michael, Gallant, Peter, Walz, Susanne, Schlosser, Andreas, Cramer, Patrick, Eilers, Martin, Wolf, Elmar
格式: Artigo
語言:Inglês
出版: Cell Press 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527870/
https://ncbi.nlm.nih.gov/pubmed/30928206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.02.031
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