PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase

The mitotic kinase AURORA-A is essential for cell cycle progression and is considered a priority cancer target. While the catalytic activity of AURORA-A is essential for its mitotic function, recent reports indicate an additional non-catalytic function, which is difficult to target by conventional s...

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Vydáno v:Nat Chem Biol
Hlavní autoři: Adhikari, Bikash, Bozilovic, Jelena, Diebold, Mathias, Schwarz, Jessica Denise, Hofstetter, Julia, Schröder, Martin, Wanior, Marek, Narain, Ashwin, Vogt, Markus, Stankovic, Nevenka Dudvarski, Baluapuri, Apoorva, Schönemann, Lars, Eing, Lorenz, Bhandare, Pranjali, Kuster, Bernhard, Schlosser, Andreas, Heinzlmeir, Stephanie, Sotriffer, Christoph, Knapp, Stefan, Wolf, Elmar
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610535/
https://ncbi.nlm.nih.gov/pubmed/32989298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-00652-y
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