PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase

The mitotic kinase AURORA-A is essential for cell cycle progression and is considered a priority cancer target. While the catalytic activity of AURORA-A is essential for its mitotic function, recent reports indicate an additional non-catalytic function, which is difficult to target by conventional s...

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Publicado no:Nat Chem Biol
Main Authors: Adhikari, Bikash, Bozilovic, Jelena, Diebold, Mathias, Schwarz, Jessica Denise, Hofstetter, Julia, Schröder, Martin, Wanior, Marek, Narain, Ashwin, Vogt, Markus, Stankovic, Nevenka Dudvarski, Baluapuri, Apoorva, Schönemann, Lars, Eing, Lorenz, Bhandare, Pranjali, Kuster, Bernhard, Schlosser, Andreas, Heinzlmeir, Stephanie, Sotriffer, Christoph, Knapp, Stefan, Wolf, Elmar
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610535/
https://ncbi.nlm.nih.gov/pubmed/32989298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-00652-y
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