PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase

The mitotic kinase AURORA-A is essential for cell cycle progression and is considered a priority cancer target. While the catalytic activity of AURORA-A is essential for its mitotic function, recent reports indicate an additional non-catalytic function, which is difficult to target by conventional s...

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Bibliografski detalji
Izdano u:Nat Chem Biol
Glavni autori: Adhikari, Bikash, Bozilovic, Jelena, Diebold, Mathias, Schwarz, Jessica Denise, Hofstetter, Julia, Schröder, Martin, Wanior, Marek, Narain, Ashwin, Vogt, Markus, Stankovic, Nevenka Dudvarski, Baluapuri, Apoorva, Schönemann, Lars, Eing, Lorenz, Bhandare, Pranjali, Kuster, Bernhard, Schlosser, Andreas, Heinzlmeir, Stephanie, Sotriffer, Christoph, Knapp, Stefan, Wolf, Elmar
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610535/
https://ncbi.nlm.nih.gov/pubmed/32989298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-00652-y
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