Structure of human telomerase holoenzyme with bound telomeric DNA

Telomerase adds telomeric repeats at chromosome ends to compensate for telomere loss caused by incomplete genome end replication1. In humans, telomerase is upregulated during embryogenesis and in cancers, while mutations that compromise its function result in diseases2. Our previous 8 Å human telome...

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Veröffentlicht in:Nature
Hauptverfasser: Ghanim, George E., Fountain, Adam J., van Roon, Anne-Marie M, Rangan, Ramya, Das, Rhiju, Collins, Kathleen, Nguyen, Thi Hoang Duong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610991/
https://ncbi.nlm.nih.gov/pubmed/33883742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03415-4
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