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Structure of human telomerase holoenzyme with bound telomeric DNA
Telomerase adds telomeric repeats at chromosome ends to compensate for telomere loss caused by incomplete genome end replication1. In humans, telomerase is upregulated during embryogenesis and in cancers, while mutations that compromise its function result in diseases2. Our previous 8 Å human telome...
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| Pubblicato in: | Nature |
|---|---|
| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7610991/ https://ncbi.nlm.nih.gov/pubmed/33883742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03415-4 |
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