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Structure of human telomerase holoenzyme with bound telomeric DNA

Telomerase adds telomeric repeats at chromosome ends to compensate for telomere loss caused by incomplete genome end replication1. In humans, telomerase is upregulated during embryogenesis and in cancers, while mutations that compromise its function result in diseases2. Our previous 8 Å human telome...

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Xehetasun bibliografikoak
Argitaratua izan da:Nature
Egile Nagusiak: Ghanim, George E., Fountain, Adam J., van Roon, Anne-Marie M, Rangan, Ramya, Das, Rhiju, Collins, Kathleen, Nguyen, Thi Hoang Duong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2021
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610991/
https://ncbi.nlm.nih.gov/pubmed/33883742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03415-4
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