Structure of human telomerase holoenzyme with bound telomeric DNA

Telomerase adds telomeric repeats at chromosome ends to compensate for telomere loss caused by incomplete genome end replication1. In humans, telomerase is upregulated during embryogenesis and in cancers, while mutations that compromise its function result in diseases2. Our previous 8 Å human telome...

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Udgivet i:Nature
Main Authors: Ghanim, George E., Fountain, Adam J., van Roon, Anne-Marie M, Rangan, Ramya, Das, Rhiju, Collins, Kathleen, Nguyen, Thi Hoang Duong
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610991/
https://ncbi.nlm.nih.gov/pubmed/33883742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03415-4
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