Structure of human telomerase holoenzyme with bound telomeric DNA

Telomerase adds telomeric repeats at chromosome ends to compensate for telomere loss caused by incomplete genome end replication1. In humans, telomerase is upregulated during embryogenesis and in cancers, while mutations that compromise its function result in diseases2. Our previous 8 Å human telome...

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Detaylı Bibliyografya
Yayımlandı:Nature
Asıl Yazarlar: Ghanim, George E., Fountain, Adam J., van Roon, Anne-Marie M, Rangan, Ramya, Das, Rhiju, Collins, Kathleen, Nguyen, Thi Hoang Duong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610991/
https://ncbi.nlm.nih.gov/pubmed/33883742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03415-4
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