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Structural basis of human telomerase recruitment by TPP1-POT1
Telomerase maintains genome stability by extending the 3’ telomeric repeats at eukaryotic chromosome ends, thereby counterbalancing progressive loss caused by incomplete genome replication. In mammals, telomerase recruitment to telomeres is mediated by TPP1, which assembles as a heterodimer with POT...
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| Yayımlandı: | Science |
|---|---|
| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2022
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7612489/ https://ncbi.nlm.nih.gov/pubmed/35201900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abn6840 |
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