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Cryo-EM structure of substrate-bound human telomerase holoenzyme
Telomerase adds telomeric repeats to chromosome ends to balance incomplete replication. Telomerase regulation is implicated in cancer, aging and other human diseases, but progress towards telomerase clinical manipulation is hampered by the lack of structural data. Here we present the cryo-electron m...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6223129/ https://ncbi.nlm.nih.gov/pubmed/29695869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0062-x |
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